Collected Literature
1,750 Patients Show Intradiscal Oxygen-Ozone 80%/75% Effective at 6mo/18mo
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Citation:
Muto M, Andreula C, Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroradiol. 2004 Jun;31(3):183-9. doi: 10.1016/s0150-9861(04)96989-1. PMID: 15356443.325503.
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Patients:
1750 @ 6 mo. 1400 @ 18 mo.
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Design:
Retrospective review.
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Safety:
No reported adverse events.
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Effectiveness:
80% success rate and 20% failure rate in 1750 patients followed up to 6 months. Success dropped to 75% and failure increased at 25% in 1400 followed up to 18 months.
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Author Comment:
Failures mostly related to calcified herniated disk; spinal canal stenosis; recurrent herniated disk with epidural fibrosis; small descending herniated disk at the level of the lateral recess.