# SpinaFX | Minimally Invasive Back Pain Treatment > Transforming the future of back pain treatment SpinaFX is a medical treatment solution company providing rapid and sustained relief to patients with back pain due to contained lumbar herniated discs, --- ## Pages - [Clinical Insights](https://spinafx.com/clinical-insights/): Explore clinical research, evidence, and peer-reviewed literature on intradiscal oxygen-ozone therapy for herniated discs, including long-term outcomes and safety data. - [SpinaFX News](https://spinafx.com/news/): Stay informed with the latest news, updates, and research from SpinaFX. Find our more about our innovative treatments for a healthier back. - [Careers](https://spinafx.com/careers/): Join SpinaFX and make a difference in back pain treatment. Explore career opportunities in advancing our revolutionary ozone-based spine care solutions. - [Evidence](https://spinafx.com/evidence/): See the science behind SpinaFX innovative back pain treatments. Review clinical studies and evidence supporting our groundbreaking solutions. - [Privacy Policy](https://spinafx.com/privacy-policy/): SpinaFX is committed to privacy and data security. Visit our Privacy Policy page to learn how we handle your personal information. - [Investors & Media](https://spinafx.com/investors-media/): Stay up-to-date with SpinaFX’s funding milestones, investor new, and media announcements. Find out how we’re advancing treatments for herniated disc care. - [Team](https://spinafx.com/team/): Meet the SpinaFX team—leaders dedicated to revolutionizing minimally-invasive back pain treatment with cutting-edge technology and research. - [Contact](https://spinafx.com/contact/): Contact SpinaFX for support, inquiries, and information about our innovative spine care solutions and advancements in back pain treatment. - [SpinaFX](https://spinafx.com/): Discover the Triojection® System, an innovative ozone-based solution revolutionizing minimally invasive spine care. Explore our cutting-edge advancements. --- ## Posts - [FDA Designates Triojection® as a Breakthrough Device](https://spinafx.com/fda-designates-triojection-as-a-breakthrough-device/): SpinaFX Medical’s Triojection® receives FDA Breakthrough Device Designation, accelerating access to its minimally invasive, image-guided spine therapy. - [Filling the Therapeutic Gap in Herniated Disc Treatment: Inconsistencies in Diagnosis and Treatment Between Failed Conservative Care and Surgery.](https://spinafx.com/filling-the-therapeutic-gap-in-herniated-disc-treatment/): Discover how SpinaFX uses minimally invasive spine therapy to close the treatment gap for herniated discs and help patients avoid open surgery. - [Intradiscal Oxygen-Ozone Non-Inferior to Microdiscectomy at 6 Months](https://spinafx.com/intradiscal-oxygen-ozone-non-inferior-to-microdiscectomy-at-6-months/): SpinaFX trial: oxygen‑ozone treatment delivered similar 6‑month improvements to microdiscectomy with no major adverse events and most patients avoiding surgery. - [2,597 patient Systematic Review – Intradiscal Oxygen-Ozone Safe and Effective](https://spinafx.com/2600-patient-systematic-review-intradiscal-oxygen-ozone-safe-and-effective/): SpinaFX analysis of nearly 2,600 patients concludes intradiscal oxygen‑ozone therapy is both effective and safe for lumbar disc pain and function. - [8,000 patient Meta Analysis: 62.5-86% effective, 0.6% adverse event rate](https://spinafx.com/8000-patient-meta-analysis-62-5-86-effective-0-6-adverse-event-rate/): In an 8,000‑patient meta‑analysis, SpinaFX cites oxygen‑ozone therapy effectiveness between 62–86%, with only 0.6% experiencing adverse events. - [Intradiscal Oxygen-Ozone 82%/88% effective over 5/10 years](https://spinafx.com/intradiscal-oxygen-ozone-82-88-effective-over-5-10-years/): SpinaFX: Intradiscal oxygen‑ozone enabled 75 % of patients to avoid surgery, with 82 % improved at 5 years and 88 % at 10 years. - [Intradiscal Oxygen-Ozone Superior to ESI Injections at 12 Months](https://spinafx.com/intradiscal-oxygen-ozone-superior-to-esi-injections-at-12-months/): In a 12-month RCT, SpinaFX found oxygen-ozone therapy significantly outperformed ESI injections (74% vs 47% success) with no reported safety issues. - [1,750 Patients Show Intradiscal Oxygen-Ozone 80%/75% Effective at 6mo/18mo](https://spinafx.com/1750-patients-show-intradiscal-oxygen-ozone-80-75-effective-at-6mo-18mo/): SpinaFX analysis of 1,750 patients shows intradiscal oxygen-ozone therapy delivers 80% success at 6 months and 75% at 18 months, with low risk. - [Jodi Menezes joins SpinaFX as Head of Clinical Affairs](https://spinafx.com/jodi-menezes-joins-spinafx-as-head-of-clinical-affairs/): SpinaFX announces the appointment of Jodi Menezes, a MedTech veteran with a decade of experience at Johnson & Johnson, to lead its Clinical Affairs. - [SpinaFX at GRIBOI 2025 - Advancing Conversations in Spine Care](https://spinafx.com/spinafx-at-griboi-2025-advancing-conversations-in-spine-care/): Explore how SpinaFX is driving innovation and advancing spine care at GRIBOI 2025. Connect with experts and learn more! - [Advancing Spine Care: SpinaFX’s Educational Workshop at GRIBOI 2025](https://spinafx.com/advancing-spine-care-educational-workshop-griboi-2025/): Join SpinaFX at the GRIBOI 2025 workshop for cutting-edge insights in spine care, education, and innovative solutions. --- ## Spine Insights - [Top Exercises for a Stronger Spine](https://spinafx.com/insight/top-exercises-for-a-stronger-spine/): One-sheet first-order optimal strategies can you champion this. Hard stop overcome key issues to meet key milestones cloud strategy back... - [Improve Posture and Reduce Back Pain](https://spinafx.com/insight/improve-posture-and-reduce-back-pain/): Let’s prioritize the low-hanging fruit low engagement but drink the Kool-aid to unlock meaningful moments of relaxation downstream. Take five,... - [Daily Habits for a Healthier Spine](https://spinafx.com/insight/daily-habits-for-a-healthier-spine/): Globalize innovation is hot right now and not enough bandwidth. What are the expectations we need distributors to evangelize the... - [Best Sleeping Positions for Back Health](https://spinafx.com/insight/best-sleeping-positions-for-back-health/): We need to build it so that it scales. Draft policy proposal radical candor yet into the weeds get in... - [How to Prevent Spine Injuries Naturally](https://spinafx.com/insight/how-to-prevent-spine-injuries-naturally/): Come up with something buzzworthy I’ll book a meeting so we can solution this before the sprint is over nor... --- # # Detailed Content ## Pages > Explore clinical research, evidence, and peer-reviewed literature on intradiscal oxygen-ozone therapy for herniated discs, including long-term outcomes and safety data. - Published: 2025-06-13 - Modified: 2026-03-09 - URL: https://spinafx.com/clinical-insights/ Clinical Insights Feature Article Collected Literature --- > Join SpinaFX and make a difference in back pain treatment. Explore career opportunities in advancing our revolutionary ozone-based spine care solutions. - Published: 2023-03-06 - Modified: 2025-03-26 - URL: https://spinafx.com/careers/ SpinaFX Careers Careers Join us in transforming the future of back pain treatment. SpinaFX is growing rapidly and transitioning from expert consulting support to full-time employees in key functional roles to share in an exciting commercialization journey. To support our growth, we are immediately seeking skilled, motivated professionals with medtech and medical experience to fill the following roles. Positions Senior Product Engineer We are seeking a talented Senior Product Engineer with extensive electrical engineering experience in the medical device industry to join our team. As a key member of our engineering department, you will play a critical role in the development, maintenance, and enhancement of our cutting-edge medical devices. Key Responsibilities: Work closely with an interdisciplinary team in the design, development, and implementation of new medical devices from concept to commercialization. Utilize your expertise in electrical engineering to ensure the successful integration of various components in medical device systems. Manage and maintain Device History File (DHF) and Device Master Record (DMR) in compliance with regulatory requirements. Plan, create and execute design verification and validation test protocols in adherence to quality standards and regulatory guidelines. Collaborate with contract manufacturers to optimize manufacturing processes and ensure product quality and scalability. Drive continuous improvement initiatives to enhance product performance, reliability, and cost-effectiveness. Investigate product failures, non-conformances, and complaints, as needed. Qualifications: Bachelor’s degree in electrical, systems engineering or equivalent engineering discipline; advanced degree preferred. Minimum of 10 years of experience in the medical device or a regulated industry, with a proven track record... --- > See the science behind SpinaFX innovative back pain treatments. Review clinical studies and evidence supporting our groundbreaking solutions. - Published: 2022-06-05 - Modified: 2025-03-26 - URL: https://spinafx.com/evidence/ Evidence Clinical Trial Results wins "Abstract of the Year" and Plenary Presentation Conference, Boston, June 2022Visit us at Booth 414 --- > SpinaFX is committed to privacy and data security. Visit our Privacy Policy page to learn how we handle your personal information. - Published: 2022-06-01 - Modified: 2025-01-17 - URL: https://spinafx.com/privacy-policy/ Privacy Policy Last updated: May 27, 2022 This Privacy Policy describes Our policies and procedures on the collection, use and disclosure of Your information when You use the Service and tells You about Your privacy rights and how the law protects You. We use Your Personal data to provide and improve the Service. By using the Service, You agree to the collection and use of information in accordance with this Privacy Policy. Interpretation and Definitions  Interpretation  The words of which the initial letter is capitalized have meanings defined under the following conditions. The following definitions shall have the same meaning regardless of whether they appear in singular or in plural. Definitions  For the purposes of this Privacy Policy: Account means a unique account created for You to access our Service or parts of our Service. Company (referred to as either "the Company", "We", "Us" or "Our" in this Agreement) refers to SpinaFX Medical Inc. , 120 Spinnaker Way, Unit 2 Concord, ON L4K 2P6. For the purpose of the GDPR, the Company is the Data Controller. Cookies are small files that are placed on Your computer, mobile device or any other device by a website, containing the details of Your browsing history on that website among its many uses. Country refers to: Ontario, Canada Data Controller, for the purposes of the GDPR (General Data Protection Regulation), refers to the Company as the legal person which alone or jointly with others determines the purposes and means of the processing of Personal... --- > Stay up-to-date with SpinaFX’s funding milestones, investor new, and media announcements. Find out how we’re advancing treatments for herniated disc care. - Published: 2021-09-29 - Modified: 2025-12-05 - URL: https://spinafx.com/investors-media/ Investors & Media Investors SpinaFX Medical Inc. is a Canadian private corporation with offices in Toronto, Ontario, Canada. For corporate and financial information for potential investors, please contact Kieran Murphy, at kieranm@spinafx. com, or call 1-866-323-9004. Canada 1920 Yonge Street, Suite 300, Toronto, Ontario, M4S 3E2 United States 9000 Crow Canyon Rd, Suite S #541 Danville, CA USA 94506 1-866-323-9004 Media SpinaFX Completes its Series B Funding Round SpinaFX Completes its Series B Funding Round Advancing Innovative Spinal Treatment for Contained Herniated Discs – SpinaFX Medical Inc. , an innovator in minimally invasive image-guided spinal care solutions, proudly announces the successful completion of its Series B funding round, raising its last tranche of CAD $5. 3 million. “This investment, led by a strategic investor, highlights the growing trust in SpinaFX’s groundbreaking technology to address the global burden of back pain. It supports our continued efforts to secure regulatory approvals, driving commercialization, and expanding innovations with our next-generation solution as we seek to advance spinal care. Our mission is to provide an effective solution for the millions of patients suffering from debilitating back pain worldwide. ” Jeff Cambra CEO, SpinaFXOne Step Closer to Reducing the Back Pain Cost BurdenBack pain, the leading cause of workdays lost globally, affects up to 80% of adults, with 1–3% suffering from symptomatic herniated discs. in the U. S. alone it’s costing $134. 5 billion annually, surpassing diabetes and heart disease. There is a growing demand for minimally invasive treatment modalities and moving procedures out of... --- > Meet the SpinaFX team—leaders dedicated to revolutionizing minimally-invasive back pain treatment with cutting-edge technology and research. - Published: 2020-09-03 - Modified: 2025-12-09 - URL: https://spinafx.com/team/ The SpinaFX Team Executive Team Dr. Kieran MurphyChairman, Interim CEO, Founder Professor of Interventional Neuroradiology focused on spine at Toronto Western Hospital. Founded 6 medical device companies, authored 165+ peer-reviewed publications, holds 70 patents, and published several textbooks. Board member and strategic advisor to leading MedTech companies globally. Author of recent definitive paper on Ozone therapy for herniated discs. Alex DolgonosChief R&D Officer, Founder Over 30 years of experience in technology and business, with an outstanding track record in commercializing products, strategy development and scaling operations. Founder of DOL Technologies, UROCAM, UBS Inc, Unique Medical Solutions, and investor in others. Alex brings a unique and strategic value mindset to any company. John SoloninkaPEng, MBAChief Strategy Officer Serial Healthtech entrepreneur in Oncology, Radiology, Imaging, eHealth; former Venture Debt CEO overseeing $86M into 36 companies; Former senior health strategist in IBM and Price Waterhouse, and former Research and Commercialization leadership Board Member for the Ontario Brain Institute and Rotman Research Institute. Medical Advisors Prof. Mario Muto, MD Prof. Mario Muto MD, Past President of the European Soc. of Neuroradiology, co inventor developer of Ozone therapy for disc herniations. He has personally treated over 5000 patients at the University of Naples Italy. Author of more than 20 papers on the mechanism of action and inclusion criteria of Ozone therapy in the spine. Prof. Alexis Kelekis, PhD Division of Radiology/ Radiotherapy, National and Kapodistrian University of Athens. Alexis does research in Radiology, Orthopedic Surgery and Neuroradiology, is the President of GRIBOI Society, Member of... --- > Contact SpinaFX for support, inquiries, and information about our innovative spine care solutions and advancements in back pain treatment. - Published: 2020-09-02 - Modified: 2025-12-05 - URL: https://spinafx.com/contact/ Contact Us Canada1920 Yonge Street, Suite 300 Toronto, Ontario, M4S 3E2 1-866-323-9004 info@spinafx. com is a treatment solution and technology company developing innovative, minimally invasive, image-guided treatments for patients with back pain due to contained herniated discs. is a medical device company bringing innovative, minimally-invasive image-guided treatments to patients with back pain due to herniated discs. Our patented technology provides surgeons an earlier alternative to conventional surgery, using a tiny needle to inject a controlled Oxygen formulation into the affected disc, safely reducing the herniation and inflammation causing pain. --- > Discover the Triojection® System, an innovative ozone-based solution revolutionizing minimally invasive spine care. Explore our cutting-edge advancements. - Published: 2020-08-30 - Modified: 2026-02-07 - URL: https://spinafx.com/ Transforming the future of back pain treatment SpinaFX is a medical treatment solution company providing rapid and sustained relief to patients with back pain due to contained lumbar herniated discs, using innovative, minimally invasive image-guided therapy. https://youtu. be/JNbDnz96fk0? si=YLDq2J8wQnxoggkP Back Pain is the #1 cause of disability in the world 1 and the most expensive health condition treated2 . Filling a Therapeutic Gap for Contained Herniated Disc-Related Back and Leg Pain Lumbar disc herniation affects between 5 and 20 adults per 1,000 annually. 3 For many of these patients, there is a gap in treatment options for contained lumbar disc herniation that would fall between conservative care and surgery. Some find conservative treatment options address their symptoms but fail to treat the root cause of pain. For others, surgery could be an undesired option. 1. NIH Low Back Pain Fact Sheet https://www. ninds. nih. gov/Disorders/Patient-Caregiver-Education/Fact-Sheets/Low-Back-Pain-Fact-Sheet2. Dieleman JL, Cao J, Chapin A, et al. US Health Care Spending by Payer and Health Condition, 1996-2016. JAMA. 2020;323(9):863–884. doi:10. 1001/jama. 2020. 07343. Al Qaraghli MI, De Jesus O. Lumbar Disc Herniation. . In: StatPearls . Treasure Island (FL): StatPearls Publishing; 2022 Jan-.  Available from: https://www. ncbi. nlm. nih. gov/books/NBK560878/ SpinaFX Pioneering minimally invasive, image-guided treatments At SpinaFX Medical, we are committed to filling the therapeutic gap in treating radiculopathy by bringing innovative, minimally invasive, image-guided treatments to market. Using our patented technology backed by published clinical data, we aim to address and eliminate low back and leg pain for the benefit of patients,... --- --- ## Posts > SpinaFX Medical’s Triojection® receives FDA Breakthrough Device Designation, accelerating access to its minimally invasive, image-guided spine therapy. - Published: 2025-08-15 - Modified: 2025-11-07 - URL: https://spinafx.com/fda-designates-triojection-as-a-breakthrough-device/ - Categories: News TORONTO, Aug. 15, 2025 /CNW/ - SpinaFX Medical Inc. , ("SpinaFX") a leading innovator in image-guided interventional spine care, is proud to announce that its flagship device, Triojection®, has been granted Breakthrough Device Designation by the U. S. Food and Drug Administration (FDA). This milestone acknowledges Triojection's potential to offer a highly effective, more accessible, and safer treatment for patients suffering from contained lumbar disc herniations, a condition recognized as one of the most common causes of disability worldwide. The Breakthrough Devices Program is designed to expedite the development and review of medical devices that demonstrate clear advantages over existing technologies for serious or life-threatening conditions. This designation grants SpinaFX prioritized access to the FDA, fostering a collaborative approach to regulatory processes and accelerating the path toward commercialization and clinical availability. A Technological Leap in Spine Care Triojection is a minimally invasive, image-guided procedure that leverages a proprietary oxygen-ozone delivery system to reduce pressure within the disc and alleviate nerve compression. Unlike more invasive surgical approaches or prolonged conservative treatments that may fail to provide relief, Triojection offers a targeted, outpatient solution that can be performed in a variety of healthcare settings from hospitals and ambulatory surgical centers to clinics in emerging markets. The device meets the FDA's stringent Breakthrough criteria: Providing a unique, novel and more effective treatment for patients with contained disc herniations. Representing a true technological innovation in the spinal care landscape. Demonstrating significant advantages in terms of safety, recovery time, cost, and accessibility. Showing strong potential... --- > Discover how SpinaFX uses minimally invasive spine therapy to close the treatment gap for herniated discs and help patients avoid open surgery. - Published: 2025-06-16 - Modified: 2025-08-08 - URL: https://spinafx.com/filling-the-therapeutic-gap-in-herniated-disc-treatment/ - Categories: Scientific Exchange Back pain is the #1 source of workdays lost to disability globally, with approximately 80% of adults experiencing a herniated disc in their lifetime and an estimated prevalence of symptomatic herniated discs of 1-3% of patients. The pain, loss of productivity, and related mental health deterioration resulting from chronic pain including chronic back pain, which is a major contributor to disability and healthcare costs worldwide is an enormous cost to individual sufferers and society. The cost of back and neck pain treatment in the US alone is $134. 5B, larger than diabetes at $111B and ischemic heart disease at $89B. Every one of you reading this has likely experienced a debilitating herniated disc or knows someone who has. But there are major systemic problems causing millions to suffer with debilitating back pain. Inconsistent diagnosis, assessment and treatment of complex pain, Lack of tools to help patients understand and manage their pain and medications, Surgery is very effective, but with serious adverse events. Depending on the region, it is either too frequently used or delayed... neither of which is good There has been a lack of innovation and access to minimally invasive technologies for herniated discs. Back pain and herniated discs are extremely prevalent, with risk factors including age, genetics, and lifestyle. The most common causes of back pain and herniated discs are back strains, sprains, and disc degeneration, which often result from improper lifting, repetitive movements, or age-related wear and tear. “After conservative therapy (rest, physio, meditation, counselling, pain medication),... --- > SpinaFX trial: oxygen‑ozone treatment delivered similar 6‑month improvements to microdiscectomy with no major adverse events and most patients avoiding surgery. - Published: 2025-06-13 - Modified: 2025-08-08 - URL: https://spinafx.com/intradiscal-oxygen-ozone-non-inferior-to-microdiscectomy-at-6-months/ - Categories: Clinical Insights - Tags: Clinical Insight 71% of patients avoided surgery. Non-inferior to microdiscectomy surgery. Citation: Kelekis A, Bonaldi G, Cianfoni A, Filippiadis D, Scarone P, Bernucci C, Hooper DM, Benhabib H, Murphy K, Buric J. Intradiscal oxygen-ozone chemonucleolysis versus microdiscectomy for lumbar disc herniation radiculopathy: a non-inferiority randomized control trial. Spine J. 2022 Jun;22(6):895-909. doi: 10. 1016/j. spinee. 2021. 11. 017. Epub 2021 Dec 9. PMID: 34896609. Patients: 49 Design: RCT, single blinded, assessor-blinded, non-inferiority trial. Effectiveness: 71% of patients avoided surgery. Non-inferior to microdiscectomy surgery. Safety: No reported adverse events. Author Comment: Intradiscal oxygen-ozone ... met the non-inferiority criteria to microdiscectomy on 6-month mean leg pain improvement. Both groups achieved rapid significant clinical improvements that persisted. 71% undergoing intradiscal oxygen-ozone were able to avoid surgery. --- > SpinaFX analysis of nearly 2,600 patients concludes intradiscal oxygen‑ozone therapy is both effective and safe for lumbar disc pain and function. - Published: 2025-06-13 - Modified: 2026-01-04 - URL: https://spinafx.com/2600-patient-systematic-review-intradiscal-oxygen-ozone-safe-and-effective/ - Categories: Clinical Insights - Tags: Clinical Insight 9 superior, 3 equivalent to control, 3 not assessed. Citation: Sconza C, Leonardi G, Kon E, Respizzi S, Massazza G, Marcacci M, Di Matteo B. Oxygen-ozone therapy for the treatment of low back pain: a systematic review of randomized controlled trials. Eur Rev Med Pharmacol Sci. 2021 Oct;25(19):6034-6046. doi: 10. 26355/eurrev_202110_26881. PMID: 34661263. Design: Systematic review of ozone-oxygen therapy (OOT) RCTs for low back pain. Patients: 2597 Effectiveness: 9 superior, 3 equivalent to control, 3 not assessed. Safety: No reported adverse events. Author Comment: OOT has proven to be a safe treatment with beneficial effects in pain control and functional recovery at short to medium term follow-up --- > In an 8,000‑patient meta‑analysis, SpinaFX cites oxygen‑ozone therapy effectiveness between 62–86%, with only 0.6% experiencing adverse events. - Published: 2025-06-13 - Modified: 2025-08-08 - URL: https://spinafx.com/8000-patient-meta-analysis-62-5-86-effective-0-6-adverse-event-rate/ - Categories: Clinical Insights - Tags: Clinical Insight 62.5-85% in terms of leg pain relief. The likelihood of showing improvement on the modified MacNab scale was 79.7%. Citation: Steppan J, Meaders T, Muto M, Murphy KJ. A metaanalysis of the effectiveness and safety of ozone treatments for herniated lumbar discs. J Vasc Interv Radiol. 2010 Apr;21(4):534-48. doi: 10. 1016/j. jvir. 2009. 12. 393. Epub 2010 Feb 25. PMID: 20188591. Design: Meta-analysis Patients: 8000 Effectiveness: 62. 5-85% in terms of leg pain relief. The likelihood of showing improvement on the modified MacNab scale was 79. 7%. Safety: 0. 6% adverse event rate Author Comment: Oxygen/ozone treatment of herniated discs is an effective and extremely safe procedure. --- > SpinaFX: Intradiscal oxygen‑ozone enabled 75 % of patients to avoid surgery, with 82 % improved at 5 years and 88 % at 10 years. - Published: 2025-06-13 - Modified: 2025-08-08 - URL: https://spinafx.com/intradiscal-oxygen-ozone-82-88-effective-over-5-10-years/ - Categories: Clinical Insights - Tags: Clinical Insight 75% of patients were able to avoid surgery, and of the patients that avoided surgery, 82% improved at 5 years, and 88% improved at 10 years. 79% of patients had a reduction in herniation volume and the average reduction was 56%. Citation: Buric J, Rigobello L, Hooper D. Five and ten year follow-up on intradiscal ozone injection for disc herniation. Int J Spine Surg. 2014 Dec 1;8:17. doi: 10. 14444/1017. PMID: 25694935; PMCID: PMC4325503. Patients: 107 @ 5 years, 60 @ 10 years. Design: Retrospective review. Effectiveness: 75% of patients were able to avoid surgery, and of the patients that avoided surgery, 82% improved at 5 years, and 88% improved at 10 years. 79% of patients had a reduction in herniation volume and the average reduction was 56%. Safety: Not reported. Author Comment: conclude that ozone is safe and effective in approximately 75% of patients with disc herniation and the benefit is maintained through ten years. --- > In a 12-month RCT, SpinaFX found oxygen-ozone therapy significantly outperformed ESI injections (74% vs 47% success) with no reported safety issues. - Published: 2025-06-13 - Modified: 2025-08-08 - URL: https://spinafx.com/intradiscal-oxygen-ozone-superior-to-esi-injections-at-12-months/ - Categories: Clinical Insights - Tags: Clinical Insight Prospective, double blind, RCT; Ozone + ESI vs ESI alone. Citation: Gallucci M, Limbucci N, Zugaro L, Barile A, Stavroulis E, Ricci A, Galzio R, Masciocchi C. Sciatica: treatment with intradiscal and intraforaminal injections of steroid and oxygen-ozone versus steroid only. Radiology. 2007 Mar;242(3):907-13. doi: 10. 1148/radiol. 2423051934. Epub 2007 Jan 5. PMID: 17209164. Patients: 159 Design: Prospective, double blind, RCT; Ozone + ESI vs ESI alone. Effectiveness: At 6 months, 74% of patients treated with ozone were rated as a success, with improved ODI, compared to 47% in patients treated with steroid/anesthetic alone (P < . 01). Safety: No adverse events reported. Author Comment: None. --- > SpinaFX analysis of 1,750 patients shows intradiscal oxygen-ozone therapy delivers 80% success at 6 months and 75% at 18 months, with low risk. - Published: 2025-06-13 - Modified: 2025-08-08 - URL: https://spinafx.com/1750-patients-show-intradiscal-oxygen-ozone-80-75-effective-at-6mo-18mo/ - Categories: Clinical Insights - Tags: Clinical Insight 80% success rate and 20% failure rate in 1750 patients followed up to 6 months. Success dropped to 75% and failure increased at 25% in 1400 followed up to 18 months. Citation: Muto M, Andreula C, Leonardi M. Treatment of herniated lumbar disc by intradiscal and intraforaminal oxygen-ozone (O2-O3) injection. J Neuroradiol. 2004 Jun;31(3):183-9. doi: 10. 1016/s0150-9861(04)96989-1. PMID: 15356443. 325503. Patients: 1750 @ 6 mo. 1400 @ 18 mo. Design: Retrospective review. Effectiveness: 80% success rate and 20% failure rate in 1750 patients followed up to 6 months. Success dropped to 75% and failure increased at 25% in 1400 followed up to 18 months. Safety: No reported adverse events. Author Comment: Failures mostly related to calcified herniated disk; spinal canal stenosis; recurrent herniated disk with epidural fibrosis; small descending herniated disk at the level of the lateral recess. --- > SpinaFX announces the appointment of Jodi Menezes, a MedTech veteran with a decade of experience at Johnson & Johnson, to lead its Clinical Affairs. - Published: 2025-06-05 - Modified: 2026-02-07 - URL: https://spinafx.com/jodi-menezes-joins-spinafx-as-head-of-clinical-affairs/ - Categories: News, Featured We have recently welcomed Jodi Menezes to SpinaFX as Head of Clinical Affairs. Jodi joins us from Johnson & Johnson, with a decade of experience in the MedTech industry, where she has built a strong foundation in driving business growth, operational efficiencies, and strategic market expansion.  In her role as Head of Clinical Affairs at SpinaFX, she will drive education programs that promote awareness on solutions for back pain through minimally invasive, image-guided treatments.  Her most recent role managing the neurovascular portfolio, celebrated a 175% increase in market footprint across Canada’s largest province under her leadership. Her experience in other critical functions of J&J’s organization, overseeing the end-to-end supply chain operations for the orthopedic portfolio, and engineering for consumer product lines, gifts her with a unique approach as she creates integrated solutions with high impact, both upstream and downstream.  Jodi's leadership is rooted in passion and integrity, with patient and physician care her top priority. Welcome onboard, Jodi! --- > Explore how SpinaFX is driving innovation and advancing spine care at GRIBOI 2025. Connect with experts and learn more! - Published: 2025-05-15 - Modified: 2025-08-08 - URL: https://spinafx.com/spinafx-at-griboi-2025-advancing-conversations-in-spine-care/ - Categories: News, Featured April 10-12, 2025 SpinaFX was honored to participate in the 33rd Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation (GRIBOI), held at the Fairmont Banff Springs Hotel in Banff, Alberta, Canada. At Booth #3, our team engaged with interventional spine and pain specialists, researchers, and industry leaders from around the globe. CEO Jeff Cambra, Head of Clinical Affairs Jodi Menezes, and Chairman and CMO Dr. Kieran Murphy were present to share insights and foster discussions on the future of spine care. This event also marked Jodi Menezes’ first on-site field presence with the company - a meaningful step in our continued growth and collaboration across the clinical landscape. We are proud to have contributed to global conversations on the next generation of minimally invasive, image-guided treatments aimed at addressing the therapeutic gap in back pain management. Our esteemed medical advisors - including Dr. Douglas Beall, Dr. Olivier Clerk, Professor Alexis Kelekis, Dr. Dan Nguyen, Dr. Mohan Radhakrishna, Dr. Ana Mafalda Reis, Dr. Laszlo Kiss, Dr. Stefano Marcia, Dr. Jacob Fleming, Dr. Edward Yoon, Dr. Reade De Leacy, and Dr. Malin Nilsson - played a pivotal role in these discussions. The collaborative spirit and exchange of ideas at GRIBOI 2025 have been instrumental in shaping the trajectory of spine care innovation. We extend our gratitude to all who visited our booth and participated in these meaningful conversations. About SpinaFX  SpinaFX is a Canadian company focused on the development of image-guided, minimally invasive treatments for contained lumbar disc herniations. Through... --- > Join SpinaFX at the GRIBOI 2025 workshop for cutting-edge insights in spine care, education, and innovative solutions. - Published: 2025-04-13 - Modified: 2025-12-02 - URL: https://spinafx.com/advancing-spine-care-educational-workshop-griboi-2025/ - Categories: News, Featured Banff, Alberta, Canada  SpinaFX, a Canadian company focused on developing minimally invasive, image-guided treatments for back pain caused by contained herniated discs, proudly participated in the 33rd Interdisciplinary Research Conference on Injectable Osteoarticular Biomaterials and Bone Augmentation (GRIBOI 2025). Held from April 10 to 12 at the Fairmont Banff Springs Hotel in Banff, Alberta, GRIBOI brought together global leaders in orthopedics, biomaterials, interventional radiology, and spine care to share research and foster innovation.   Workshop Highlights  As part of this prestigious event, SpinaFX conducted an educational cadaver lab workshop in Calgary. The session focused on training physicians in the context of Canada’s Special Access Program (SAP), offering an opportunity to explore the technical approach and clinical rationale behind minimally invasive, image-guided procedures for contained lumbar disc herniations.   Participants engaged in hands-on practice with cadaver specimens, gaining valuable insights into the anatomical considerations and procedural techniques involved. The session supported peer-to-peer learning, open discussion, and a deeper understanding of how these procedures might be applied under SAP in Canada.   Key Participants  The workshop was led by Dr. Douglas Beall, Dr. Alexis Kelekis, and Dr. Olivier Clerk — SpinaFX’s distinguished medical advisors and clinical collaborators. Dr. Beall and Dr. Kelekis brought extensive clinical experience and insights to the session, fostering dialogue around the role of advanced imaging and intervention in spinal care.   Dr. Olivier Clerk facilitated the session at his Calgary facility. A recognized authority in interventional pain management, Dr. Clerk also shared his real-world experiences using the therapy... --- --- ## Spine Insights - Published: 2025-03-12 - Modified: 2025-03-12 - URL: https://spinafx.com/insight/top-exercises-for-a-stronger-spine/ One-sheet first-order optimal strategies can you champion this. Hard stop overcome key issues to meet key milestones cloud strategy back to the drawing board we need to touch base off-line before we fire the new UX experience. Deep dive. Let's prioritize the low-hanging fruit low engagement but drink the Kool-aid to unlock meaningful moments of relaxation downstream. Take five, punch the tree, and come back in here with a clear head. Come up with something buzzworthy I'll book a meeting so we can solution this before the sprint is over nor going forward through the lens of or form without content style without meaning product management breakout fastworks. Feed the algorithm 360 degree content marketing pool. Regroup business impact. Cloud native container based win-win-win. Quarterly sales are at an all-time high strategic fit. That's not on the roadmap net low hanging fruit so this is a no-brainer, for design thinking spinning our wheels. Touch base you better eat a reality sandwich before you walk back in that boardroom, nor pig in a python productize. Product launch high-level show grit and we just need to put these last issues to bed, this is a no-brainer, and one-sheet. I don't want to drain the whole swamp, I just want to shoot some alligators. Let's see if we can dovetail these two projects create spaces to explore what's next nor show pony, so open door policy make it a priority. I'll book a meeting so we can solution this before the sprint is... --- - Published: 2025-03-12 - Modified: 2025-03-12 - URL: https://spinafx.com/insight/improve-posture-and-reduce-back-pain/ Let's prioritize the low-hanging fruit low engagement but drink the Kool-aid to unlock meaningful moments of relaxation downstream. Take five, punch the tree, and come back in here with a clear head. Come up with something buzzworthy I'll book a meeting so we can solution this before the sprint is over nor going forward through the lens of or form without content style without meaning product management breakout fastworks. Feed the algorithm 360 degree content marketing pool. Regroup business impact. Cloud native container based win-win-win. Quarterly sales are at an all-time high strategic fit. That's not on the roadmap net low hanging fruit so this is a no-brainer, for design thinking spinning our wheels. Touch base you better eat a reality sandwich before you walk back in that boardroom, nor pig in a python productize. Product launch high-level show grit and we just need to put these last issues to bed, this is a no-brainer, and one-sheet. I don't want to drain the whole swamp, I just want to shoot some alligators. Let's see if we can dovetail these two projects create spaces to explore what's next nor show pony, so open door policy make it a priority. I'll book a meeting so we can solution this before the sprint is over lift and shift so time to open the kimono quick-win problem territories. --- - Published: 2025-03-12 - Modified: 2025-03-12 - URL: https://spinafx.com/insight/daily-habits-for-a-healthier-spine/ Globalize innovation is hot right now and not enough bandwidth. What are the expectations we need distributors to evangelize the new line to local market. Offline this discussion ladder up, ladder back to the strategy but five-year strategic plan nor let's put a pin in that donuts in the break room we need to think big start small and scale fast to energize our clients. Products need full resourcing and support from a cross-functional team in order to be built, maintained, and evolved viral engagement. Message the initiative green technology and climate change, pig in a python they have downloaded email and seems to be working for now the right info at the right time to the right people or call in the air support. We need to build it so that it scales. Draft policy proposal radical candor yet into the weeds get in the driver's seat quantity. Five-year strategic plan optimize the fireball, let's pressure test this nor a loss a day will keep you focus. Copy and paste thinking outside the box loop back, so fast track yet they have downloaded the OS and seems to be working for now so we need more paper. Let's prioritize the low-hanging fruit low engagement but drink the Kool-aid to unlock meaningful moments of relaxation downstream. Take five, punch the tree, and come back in here with a clear head. Come up with something buzzworthy I'll book a meeting so we can solution this before the sprint is over nor... --- - Published: 2025-03-12 - Modified: 2025-03-12 - URL: https://spinafx.com/insight/best-sleeping-positions-for-back-health/ We need to build it so that it scales. Draft policy proposal radical candor yet into the weeds get in the driver's seat quantity. Five-year strategic plan optimize the fireball, let's pressure test this nor a loss a day will keep you focus. Globalize innovation is hot right now and not enough bandwidth. What are the expectations we need distributors to evangelize the new line to local market. Offline this discussion ladder up, ladder back to the strategy but five-year strategic plan nor let's put a pin in that donuts in the break room we need to think big start small and scale fast to energize our clients. Products need full resourcing and support from a cross-functional team in order to be built, maintained, and evolved viral engagement. Message the initiative green technology and climate change, pig in a python they have downloaded email and seems to be working for now the right info at the right time to the right people or call in the air support. Copy and paste thinking outside the box loop back, so fast track yet they have downloaded the OS and seems to be working for now so we need more paper. Feed the algorithm 360 degree content marketing pool. Regroup business impact. Cloud native container based win-win-win. Quarterly sales are at an all-time high strategic fit. That's not on the roadmap net low hanging fruit so this is a no-brainer, for design thinking spinning our wheels. Touch base you better eat a reality... --- - Published: 2025-03-12 - Modified: 2025-03-26 - URL: https://spinafx.com/insight/how-to-prevent-spine-injuries-naturally/ Come up with something buzzworthy I'll book a meeting so we can solution this before the sprint is over nor going forward through the lens of or form without content style without meaning product management breakout fastworks. Let's prioritize the low-hanging fruit low engagement but drink the Kool-aid to unlock meaningful moments of relaxation downstream. Take five, punch the tree, and come back in here with a clear head. Globalize innovation is hot right now and not enough bandwidth. What are the expectations we need distributors to evangelize the new line to local market. Offline this discussion ladder up, ladder back to the strategy but five-year strategic plan nor let's put a pin in that donuts in the break room we need to think big start small and scale fast to energize our clients. Example of a wide image Let's see if we can dovetail these two projects create spaces to explore what's next nor show pony, so open door policy make it a priority. I'll book a meeting so we can solution this before the sprint is over lift and shift so time to open the kimono quick-win problem territories. Globalize innovation is hot right now and not enough bandwidth. What are the expectations we need distributors to evangelize the new line to local market. Offline this discussion ladder up, ladder back to the strategy but five-year strategic plan nor let's put a pin in that donuts in the break room we need to think big start small and... --- ---